Statin Toxicity
نویسندگان
چکیده
منابع مشابه
Statin-Related Muscle Toxicity
yperlipidemia is widely recognized as one of the major risk factors for coronary heart disease (CHD). Whereas therapeutic lifestyle changes are the first-line modality for reducing low-density lipoprotein (LDL) cholesterol, many patients also require medication to achieve cholesterol level goals. Primary and secondary prevention studies have demonstrated that adequate reduction of LDL cholester...
متن کاملTransporter pharmacogenetics and statin toxicity.
Polymorphisms in transporter genes can have profound effects on statin pharmacokinetics. In particular, a common genetic variant of organic anion-transporting polypeptide 1B1 reduces the hepatic uptake of many statins, increasing the risk of statin-induced myopathy. Similarly, genetically impaired adenosine triphosphate (ATP)-binding cassette G2 transporter efflux activity results in a marked i...
متن کاملStatin Muscle Toxicity and Genetic Risk Factors
In the context of statin monotherapy, the frequency of myopathy is ~1/1,000, and the frequency of rhabdomyolysis is ~1/100,000. The frequency increases with dose [7,8]. Clinicians often measure serum CK levels, as parameter of severity, but the correlation between symptoms and CK level is incomplete. Therefore, the clinical interpretation of CK level is complex. Elevations less than three-fold ...
متن کاملEfficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity.
Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 μmol L⁻¹) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive ox...
متن کاملStatin toxicity from macrolide antibiotic coprescription: a population-based cohort study.
BACKGROUND Clarithromycin and erythromycin, but not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by CYP3A4. OBJECTIVE To measure the frequency of statin toxicity after coprescription of a statin with clarithromycin or erythromycin. DESIGN Population-based cohort study. SETTING Ontario, Canada, f...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.118.312782